MICHELA ABRAMI

Biomedical gels: structure and properties

Supervisor:

GABRIELE GRASSI

ELEONORA VIANELLO

In vivo evaluation of biomolecular mechanisms of bilirubin toxicity and pre-clinical therapies.

Supervisor:

SILVIA GAZZIN

CLAUDIO TIRIBELLI

VERONICA MARIN

Non-Alcoholic and Alcoholic Fatty Liver disease: two sides of the same coin.

Supervisor:

CLAUDIO TIRIBELLI

NATALIA ROSSO

ILARIA ANNA PIA VOTO

The Pin1 orthologue Dodo regulates heterochromatin formation and activity of transposable elements in Drosophila germline and neural tissue.

Supervisor:

FIAMMA MANTOVANI

GIANNINO DEL SAL

MARTINA CUSAN

SIGNIFICANCE OF P27 IN GROWTH AND RESPONSE TO THERAPY OF LUMINAL BREAST CANCER

Supervisor:

BARBARA BELLETTI

VALENTINA BUEMI

Telomerase regulation by non-coding RNAs

Supervisor:

STEFAN SCHOEFTNER

ELENA CAMPANER

A new covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Supervisor:

GIANNINO DEL SAL

DEBORA STELITANO

GTSE1: a novel TEAD4-E2F1 target gene involved in cell protrusions formation in Triple Negative Breast Cancer

Supervisor:

SILVANO PIAZZA

CLAUDIO SCHNEIDER

GIANLUIGI DE BENEDETTO

Characterization of polysaccharide-based vaccines against invasive nontyphoidal Salmonella disease (iNTS)

Supervisor:

PAOLA CESCUTTI

FRANCESCA MICOLI

STEFANO GAMBATO

Cathelicidin host defence peptides in cetartiodactyls – identification and characterization of novel members and modification for exploitation as anti-infective agents

Supervisor:

ALESSANDRO TOSSI

CARLOTTA PENZO

HMGA1 PROTEINS REGULATE GENE EXPRESSION IN TRIPLE-NEGATIVE BREAST CANCER CELLS THROUGH THE MODULATION OF THE EPIGENETIC CODE

Supervisor:

RICCARDO SGARRA

GUIDALBERTO MANFIOLETTI

GIULIA MARIA PIPERNO

The actin-nucleator promoting factor WASp regulates endo-lysosomal maturation and Toll-like receptor 9 signaling in Dendritic Cells.

Supervisor:

FEDERICA BENVENUTI

FRANCESCA CITRON

An integrated approach identifies mediators of local recurrence in head and neck squamous cell carcinoma

Supervisor:

GUSTAVO BALDASSARRE

BARBARA BELLETTI

ELENA VALENTINO

A mutant p53 gain of function in the oncogenic response to insulin

Supervisor:

LICIO COLLAVIN

MARZIA RAIMONDI

Regulation of autophagy by Ubiquitin Specific Peptidase 1 (USP1)

Supervisor:

CLAUDIO SCHNEIDER

VIVIANA MARIA OPINATO

Role of Mesenchymal Stromal Cells in High-Grade Serous Ovarian Cancer

Supervisor:

CLAUDIO SCHNEIDER

ROBERTO VERARDO

DARIA SICARI

Unveiling a role for mutant p53 in regulation of Unfolded Protein Response

Supervisor:

LICIO COLLAVIN

MANUEL CAPUTO

DEPDC1A, a novel SREBP1 cofactor, regulates fatty acid metabolism in breast cancer

Supervisor:

GIANNINO DEL SAL

ROSSELLA ZANIN

HMGA1 AND FOXM1 SYNERGISTICALLY REGULATE A COMMON GENE NETWORK MODULATING THE ANGIOGENESIS IN BREAST CANCER

Supervisor:

SILVIA PEGORARO

GUIDALBERTO MANFIOLETTI

MARGHERITA DEGASPERI

Optimization of BMAP-18 an anti-infective peptide for the treatment of pulmonary infection

Supervisor:

MARCO SCOCCHI

MARCO DISTEFANO

Functional characterization of the biofilm exopolysaccharide produced by Burkholderia multivorans C1576

Supervisor:

PAOLA CESCUTTI

ROSSELLA BALDINI

UNDERSTANDING THE MOLECULAR MECHANISMS UNDERLYING THE PATHOGENESIS OF OPITZ G/BBB SYNDROME EXPLOITING THE Mid1 KNOCK-OUT MOUSE MODEL

Supervisor:

GERMANA MERONI

ROMANA VIDERGAR

Complement component C1q and hyaluronic acid act as novel "signaling complex" in malignant pleural mesothelioma microenvironment to promote cancer progression

Supervisor:

ROBERTA BULLA

ANNIE ZAPPONE

Role of SFPQ function in RNA:DNA hybrids related genomic instability in telomeres

Supervisor:

STEFAN SCHOEFTNER

MASSIMO ROSSO

Oct4 pseudogene lncRNA: dissecting its role in embryonic stem cell differentiation and epigenetic silencing of its ancestral gene in trans

Supervisor:

STEFAN SCHOEFTNER

ROBERTA BENETTI

SERENA RIZZO

IDENTIFICATION AND PRODUCTION OF RECOMBINANT ANTIBODIES TARGETING WEST NILE VIRUS THROUGH NAÏVE AND IMMUNIZED PHAGE-DISPLAY LIBRARIES

Supervisor:

DANIELE SBLATTERO

BARBARA SALIS

STARD3 and the identification of new cholesterol transport inhibitor

Supervisor:

FLAVIO RIZZOLIO

GABRIELE GRASSI

RUSDINA BTE LADJU

The Importance of Death Receptor Pathway in Hepatocellular Carcinoma and It's Potential in the Development of Oligonucleotide Nanomedicine

Supervisor:

CLAUDIO TIRIBELLI

MICHELANGELO ALOISIO

APPLICATION OF A NEW MOLECULAR APPROACH BASED ON NEXT GENERATION SEQUENCING TO MONITOR THE CHIMERISM POST ALLOGENEIC HSCT

Supervisor:

ROBERTA BULLA

GIOVANNI MARIA SEVERINI

MUHAMMAD YOGI PRATAMA

TRANSLATIONAL STUDIES ON MICRORNA IN HEPATOCELLULAR CARCINOMA: FROM PREDICTIVE AND PROGNOSTIC BIOMARKERS TO MOLECULAR EFFECTORS

Supervisor:

CLAUDIO TIRIBELLI

FRANCESCA PERRONE

Development of a novel Polymer-based delivery system for siRNAs to hepatocellular carcinoma cells

Supervisor:

GABRIELE GRASSI

EMANUELA RIZZO

Characterization of anti-transglutaminase 2 (TG2) antibodies from Celiac patients by an integrated experimental and computational approach

Supervisor:

DANIELE SBLATTERO

GIORGIA MUNGO

ROLE OF p27Kip1 IN MAMMARY GLAND DEVELOPMENT AND TUMORIGENESIS IN Δ16HER2 MODEL

Supervisor:

GUSTAVO BALDASSARRE

BARBARA BELLETTI

ANNA IANZA

VALIDATION OF PREDICTIVE AND PROGNOSTIC BIOMARKERS AS A GUIDE FOR A PERSONALIZED APPROACH IN SOLID TUMOURS

Supervisor:

DANIELE GENERALI

GIANDOMENICO ROVIELLO

Tumour Infiltrating Lymphocytes and Immune-Related Genes as Predictors of Outcome in Pancreatic Adenocarcinoma

Supervisor:

DANIELE GENERALI

FRANCESCA MARANO

Optimization of a pipeline for the development of recombinant monoclonal antibodies for diagnostics

Supervisor:

DANIELE SBLATTERO

MICHELA SGUBIN

HMGA1-p27-stathmin axis promotes migration in triple-negative breast cancer cells

Supervisor:

GUSTAVO BALDASSARRE

GUIDALBERTO MANFIOLETTI

REBECCA BERTOLIO

Sterol Regulatory Element Binding Protein couples mechanical cues to lipid metabolism

Supervisor:

GIANNINO DEL SAL

NAVID SOBHANI

The predictive role of the immune system for response to therapy and survival in patients with solid tumors.

Supervisor:

DANIELE GENERALI

JAVIER FLORES GUTIÉRREZ

Mirtazapine for Rett syndrome: a candidate to improve quality of life

Supervisor:

ENRICO TONGIORGI

MARTINA MASCARO

Ruolo di TRIM18, gene che causa la sindrome di Opitz, nel controllo della ciliogenesi attraverso l'autofagia

Supervisor:

GERMANA MERONI

MAGUIE EL BOUSTANI

AP3M2, NEW MOLECULAR TARGET IN COLORECTAL CANCER THERAPY

Supervisor:

GABRIELE GRASSI

MARIA MICHELINA RASO

Characterization and immunogenicity of O-Antigen based Shigella Generalized Modules for Membrane Antigens vaccines

Supervisor:

FRANCESCA MICOLI

PAOLA CESCUTTI

MATTIA APOLLONIO

Regulation and function of tumor suppressor DAB2IP in the cellular response to mechanical inputs

Supervisor:

LICIO COLLAVIN

PAMELA VENEZIANO BROCCIA

Role of RNA:DNA hybrids management in controlling mitotic chromosome structure in human cancer cells

Supervisor:

STEFAN SCHOEFTNER

ALICE COSTA

Dissecting the role of G9a/GLP histone methyltransferases in Platinum-resistant ovarian cancer

Supervisor:

GUSTAVO BALDASSARRE

ANNALISA BIANCO

Meccanismi di protezione della bilirubina contro il danno metabolico a livello cellulare

Supervisor:

CLAUDIO TIRIBELLI

RICCARDO SOLA

Towards the design of peptide antibiotics: new insights from synthetic analogues and from natural sources

Supervisor:

MARCO SCOCCHI

SARA PETROSINO

HMGA1 MODULA L'ESPRESSIONE DEGLI ISTONI CICLO CELLULARE-DIPENDENTE, RENDENDO CELLULE RESISTENTI ALL'EPIRUBICINA PIU' SENSIBILI ALLA SUA AZIONE

Supervisor:

GUIDALBERTO MANFIOLETTI

ROBERTA CAPORALE

MODULATION OF ADIPOSE TISSUE METABOLISM BY UNACYLATED GHRELIN AND ITS RELEVANCE IN OBESITY

Supervisor:

ROCCO BARAZZONI

MARIA CONCETTA VOLPE

miR-200c prevents and reverts Lung fibrosis by down regulating Flt1 and promoting lung regeneration

Supervisor:

MARCO CONFALONIERI

ALICE GAMBELLI

ITGA6 is a key molecule in driving metastatization of platinum resistant epithelial ovarian cancer

Supervisor:

GUSTAVO BALDASSARRE

JAVAD KARIMBAYLI

Dissecting the role of CDK17 in Epithelial Ovarian Cancer

Supervisor:

GUIDALBERTO MANFIOLETTI

GUSTAVO BALDASSARRE

FILIPPO VIT

La diversificazione intraclonale nei geni IGHV nella leucemia linfatica cronica: da un approccio bioinformatico alla clinica.

Supervisor:

VALTER GATTEI

FRANCESCA RUSSO

Implicazione di p27 kip1 nell'esordio e nella progressione del carcinoma mammario luminale

Supervisor:

BARBARA BELLETTI

GUSTAVO BALDASSARRE

LORENA MUSCO

p53 context dependent role of Mir-9/KLF5/Sp1 axis in modulating response to therapy in Head and Neck Squamous Cell Carcinoma.

Supervisor:

GUSTAVO BALDASSARRE

FERAS KHARRAT

Role of Acylated Ghrelin in Adipose Tissue Metabolism and Investigation of Its Interaction with O-GlcNAc Transferase

Supervisor:

ROCCO BARAZZONI

CAMILLA TOMBARI

Role of mutant p53 as mechanosensitive regulator of amino-acid metabolism in breast cancer

Supervisor:

GIANNINO DEL SAL

FRANCESCA DI CRISTINO

The stress-activated kinase p38MAPK contributes to ATF6 activation and resistance to ER stress in cancer cells with mutant p53

Supervisor:

LICIO COLLAVIN

SRI JAYANTI

THE JANUS FACE OF BILIRUBIN: FROM NEONATAL TOXICITY TO THE POTENTIAL PROTECTION IN NEURODEGENERATIVE DISEASES

Supervisor:

SILVIA GAZZIN

CLAUDIO TIRIBELLI

ROSSELLA DE FLORIAN FANIA

Identification and characterization of therapeutic molecules affecting expression levels of the tumor suppressor DAB2IP in cancer

Supervisor:

LICIO COLLAVIN

FEDERICA DI CAMILLO

Analisi degli effetti del miR-30d sulla via di segnalazione immune cGAS/STING/IFN-I in cellule di carcinoma mammario

Supervisor:

GIANNINO DEL SAL

SALVATORE PARISI

STARD3: A new potential therapeutic target in colorectal cancer

Supervisor:

FLAVIO RIZZOLIO

MANUEL LISETTO

CARATTERIZZAZIONE BIOCHIMICA E FUNZIONALE DELLE PROTEINE TRANSGLUTAMINASI 2 DELLO ZEBRAFISH

Supervisor:

DANIELE SBLATTERO

LUCIA CELORA

COMBINING BIOINFORMATICS WITH WHOLE-CELL PATCH-CLAMP RECORDINGS TO INVESTIGATE THE ROLE OF αVβ3 INTEGRIN IN MOUSE MODELS OF ASD AND EPILEPSY

Supervisor:

FABRIZIA CESCA

LORENZO ANGELO CINGOLANI

ADRIANA DI STASI

Il peptide antimicrobico B7-005: biocompatibilità, modalità d'azione e attività antimicrobica contro i patogeni ESKAPE

Supervisor:

MARCO SCOCCHI

GIORGIA BIMBI

Local transport and translation of BDNF following synaptic potentiation

Supervisor:

ENRICO TONGIORGI

INÊS FERNANDES LAGES

Identification of Deubiquitinases (DUBs) associated with TRIM18/MID1

Supervisor:

GERMANA MERONI

LU XIONG

Role of TRIM32, the ubiquitin ligase mutated in Limb Girdle Muscular Dystrophy R8

Supervisor:

GERMANA MERONI

NOEL SALVOZA

Translational Approach for the Study of Metabolic-Associated Fatty Liver Disease (MAFLD): A Wide Spectrum Disease

Supervisor:

CLAUDIO TIRIBELLI

NATALIA ROSSO

LORAINE KAY CABRAL

Molecular profiling of liver cancer: Genetic and epigenetic variation analysis for developing potential targets for therapy

Supervisor:

CLAUDIO TIRIBELLI

CAECILIA SUKOWATI

OTTAVIA MARIA ROGGERO

Un approccio farmacologico sistemico per trattamenti innovativi volti a promuovere il recupero dell'atrofia neuronale nella sindrome di Rett

Supervisor:

ENRICO TONGIORGI

LUCA GRISETTI

The Role of Aurora Kinase A in the Development of Hepatocellular Carcinoma and in the Regulation of Programmed Death-Ligand 1

Supervisor:

CLAUDIO TIRIBELLI

DEVIS PASCUT

RICCARDO RUGGERI

Calcium channels and integrins in cortical synaptic transmission: relevance for new therapeutical targets in epilepsy

Supervisor:

LORENZO ANGELO CINGOLANI

LUCREZIA CAMICIA

The role of Multimerin-2 in pericyte recruitment and vascular stability

Supervisor:

MAURIZIO ORLANDINI

DAVIDE VIGETTI

SERENA MAIOCCHI

High throughput screening per lo studio della patogenesi del mesotelioma maligno della pleura: un approccio di riposizionamento di farmaci per sviluppare nuove terapie di combinazione.

Supervisor:

MARCO CONFALONIERI

FEDERICA DATTOLA

Identificazione di nuovi composti antivirali contro il virus dell'Encefalite da zecche (TBEV) tramite un approccio host-directed therapy

Supervisor:

ALESSANDRO MARCELLO

ALESSANDRO FERRANDO

Recruitment of H3.3 histone chaperon activity to R-loops by the Splicing-Factor Proline and Arginine Rich (SFPQ) stabilizes repetitive elements in cancer cells

Supervisor:

STEFAN SCHOEFTNER

LICIO COLLAVIN

ALESSIA PALDINO

TITIN DOWNREGULATION AFFECTS CARDIOMYOCYTES PROLIFERATION

Supervisor:

GIANFRANCO SINAGRA

ELENA PALMIERI

Investigazione di tecnologie alternative per lo sviluppo di vaccini basati su polisaccaridi

Supervisor:

PAOLA CESCUTTI

NICOLA PAVAN

NEW PERSPECTIVE IN PROSTATE CANCER DIAGNOSIS AND TREATMENT: A PIVOTAL STUDY ON EEF1A1 PROTEIN LEVELS AS POTENTIAL THERAPEUTIC TARGET AND LIQUID BIOPSY ON CFDNA OF EEF1A1, CFRNA EEF1A1 AND CFDI OF LINE-1 AS NEW DIAGNOSTIC AND PROGNOSTIC BIOMARKERS

Supervisor:

ALICE TURDO

ALCHIEDE SIMONATO

ALICJA KRAWCZUN-RYGMACZEWSKA

Understanding the pathogenic mechanisms of the ‘Spastic paraplegia, Intellectual disability, Nystagmus and Obesity’ (SINO) syndrome.

Supervisor:

FABRIZIA CESCA

FABIO BENFENATI

ANDREA BALDUIT

Evaluation of the Prognostic Power of Complement System in Malignant Pleural Mesothelioma

Supervisor:

ROBERTA BULLA

ROMAN VUERICH

Studio del cross-talk tra cardiomiociti e cellule endoteliali per promuovere la rivascolarizzazione e la rigenerazione cardiaca

Supervisor:

SERENA ZACCHIGNA

CHIARA BONCRISTIANI

Reverting therapy resistance of lung cancer cells by forcing RNA:DNA hybrid formation

Supervisor:

STEFAN SCHOEFTNER

LICIO COLLAVIN

UTSA BHADURI

On the rise of TRIM8 as a multifunctional workhorse during the course of mitosis

Supervisor:

GIUSEPPE MERLA

CLARA DEZI

La rigidità della matrice extracellulare rende cellule pre-neoplastiche con mutazioni in p53 super-competitive

Supervisor:

GIANNINO DEL SAL

FRANCESCO NAPOLETANO

LAURA COLOMINA ALFARO

Biopolimeri ricombinanti basati su HELP: una piattaforma versatile per realizzare interfacce antimicrobiche per applicazioni ortopediche

Supervisor:

ANTONELLA BANDIERA

ALESSANDRO TOSSI